Southern African Journal of HIV Medicine: Vol 17 (2016): Activity 3
The objective of this paper was to determine whether there are any correlations between plasma TFV concentrations and renal function markers in HIV-infected women receiving antiretroviral therapy (ART) containing tenofovir disoproxil fumarate (TDF); to ascertain whether there were any changes in such markers from baseline renal function values; and to compare renal function markers to a control group, which were HIV-negative women in this study.
This article provides useful information about the effect of TFV concentrations on renal function, and how renal function markers in HIV-positive women compare to those who are HIV-negative. It is also the first pilot study to determine an association between plasma TFV concentration and albuminuria in HIV-infected women in South Africa, and may make practitioners aware of the possible need for monitoring plasma TFV concentrations to detect early signs of renal impairment.
Upon completion of this module practitioners should have a clear understanding of:
- The potential effect of TFV on renal function in HIV-positive individuals.
- How renal function in HIV-positive individuals on ART compares to that of HIV-negative individuals.
- The progression of renal function in HIV-positive individuals on ART and possible reasons for such changes.
- The significance of albuminuria as an early sign of renal function loss and a risk factor for kidney disease.
Instruction for this Module
- Read the supplied reading material and complete the quiz at the end
- You need to pass the quiz and complete the course rating to generate the module certificate at the end
- You have three attempts to pass the quiz
- The pass grade is 70%
- Please click on the CPD certificate link to claim your certificate and to update your CPD Manager
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