Southern African Journal of HIV Medicine: Vol 17 (2016): Activity 3

: 2 credits
Expiry Date
: 31/12/2019
CPD Units
: 2.00 Points
: 2.8/4

The objective of this paper was to determine whether there are any correlations between plasma TFV concentrations and renal function markers in HIV-infected women receiving antiretroviral therapy (ART) containing tenofovir disoproxil fumarate (TDF); to ascertain whether there were any changes in such markers from baseline renal function values; and to compare renal function markers to a control group, which were HIV-negative women in this study.

Keywords: Plasma tenofovir; renal function; albuminuria; south africa

Reading material:

Educational Objectives

Editor's comments:
This article provides useful information about the effect of TFV concentrations on renal function, and how renal function markers in HIV-positive women compare to those who are HIV-negative. It is also the first pilot study to determine an association between plasma TFV concentration and albuminuria in HIV-infected women in South Africa, and may make practitioners aware of the possible need for monitoring plasma TFV concentrations to detect early signs of renal impairment.

Educational Outcomes:
Upon completion of this module practitioners should have a clear understanding of:

  1. The potential effect of TFV on renal function in HIV-positive individuals.
  2. How renal function in HIV-positive individuals on ART compares to that of HIV-negative individuals.
  3. The progression of renal function in HIV-positive individuals on ART and possible reasons for such changes.
  4. The significance of albuminuria as an early sign of renal function loss and a risk factor for kidney disease.

Instruction for this Module

  • Read the supplied reading material and complete the quiz at the end
  • You need to pass the quiz and complete the course rating to generate the module certificate at the end
  • You have three attempts to pass the quiz
  • The pass grade is 70%
  • Please click on the CPD certificate link to claim your certificate and to update your CPD Manager

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