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Childhood aplastic anaemia with paroxysmal nocturnal haemoglobinuria clones

Expiry Date
: 06/02/2030
CPD Units
: 1.00 Points
Rating
: Not yet rated.

This study investigates the prevalence of PNH clones in children with idiopathic aplastic anaemia (AA), finding a high occurrence (55.6%) but no significant impact on clinical severity. Early immunosuppressive therapy improves outcomes.

Keywords: paroxysmal nocturnal haemoglobinuria clones; aplastic anaemia; paediatrics; flow cytometry; HLA typing.

Reading material:

Educational Objectives

Educational Aim:

To explore the prevalence of PNH clones in children with idiopathic aplastic anaemia (AA) and assess how clone size, clinical features, and immunosuppressive therapy influence patient outcomes.

Educational Outcomes:
Upon completion of this module practitioners should have a clear understanding of:

  1. The prevalence of PNH clones
  2. Identifying clinical and laboratory differences
  3. Evaluating the impact of immunosuppressive therapy

Instructions for this Module

  • Read the supplied reading material and complete the quiz that follows;
  • You have three attempts to pass the quiz;
  • The pass grade is 70%;
  • You need to pass the quiz to claim your CPD certificate;
  • Please click on the CPD certificate link below to claim your CPD certificate and to update your CPD Manager.

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