There is no diagnostic tool able to rapidly identify or exclude infection, leading to under-recognition of non-infectious inflammatory states.





Keywords: sepsis, septic shock, critical care, infection, diagnosis

This review discusses the potential harms of O2 in the context of critical care.





Keywords: hyperoxia, hyperoxaemia, reacitve oxygen species, ARDS, sepsis, acute ischaemic stroke

South African guidelines on diagnosing circulatory and brain death.





Keywords: Brain death, circulatory death, organ donation, coma

An approach to the indications, advantages and disadvantages of the ICU patient on APRV.





Keywords: ICU, mechanical ventilation, ARDS

A narrative review of the current diagnosis and management of propofol infusion syndrome.





Keywords: propofol, mitochondria, sedation

An approach to the post-ischaemic stroke patient requiring routine or urgent surgery.





Keywords: Acute ischaemic stroke, anaesthesia, blood pressure, cerebral perfusion, endovascular therapy, haemodynamics, prevention, thrombolysis