Drug–drug Interactions and its Clinical Effects

This article provides an outline of the pharmacokinetic (PK) and pharmacodynamic (PD) mechanisms that cause drug-drug interactions, leading to serious and debilitating adverse drug reactions.

Educational Objectives

Educational Aim:
The aim of this article is to emphasise the effects of drug-drug interactions on the pharmacokinetics of drug disposition related to the absorption, distribution, metabolism and excretion mechanisms.

Educational Outcomes:
Upon completion of this module practitioners should have a clear understanding of:

1. The cells involved in the absorption, distribution, metabolism and excretion of drugs.
2. The drug metabolizing enzymes and drug transporters that are involved in drug-drug interactions.
3. The effect of inhibiting or inducing proteins through drug-drug interactions on the pharmacokinetic parameters.

Instructions for this Module

• Read the supplied reading material and complete the quiz that follows;
• You have three attempts to pass the quiz;
• The pass grade is 70%;
• You need to pass the quiz to claim your CPD certificate;
• Please click on the CPD certificate link below to claim your CPD certificate and to update your CPD Manager.

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