Mtb bacterial aggregates augment pulmonary disease pathology

Bacterial aggregates rather than similar numbers of single bacilli exacerbate Mycobacterium tuberculosis disease pathology in rabbit lungs.

Educational Objectives

Educational Aim:
The aim of this article is to elucidate disease progression after aerosolized infection of rabbits with Mtb aggregates (Mtb-Ag) vs Mtb single cells (Mtb-SC).

Editor's comments:
Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology. Communications Biology Volume 4, Article number: 1256 (2021).

Educational Outcomes:
Upon completion of this module practitioners should have a clear understanding of:

1. how the very early host response to the mechanical properties of Mtb initially implanted in the lungs (i.e. aerosolized infection with Mtb-Ag bacterial vs Mtb-SC) enhances the progression of pulmonary disease in infected lungs and,

    

2. to uncover which of the gene networks and cellular pathways associated with necrotic cell death, cytotoxicity, and increased bacillary survival are at play in the early stages of Mtb infection.
   

Instructions for this Module

• Read the supplied reading material and complete the quiz that follows;
• You have three attempts to pass the quiz;
• The pass grade is 70%;
• You need to pass the quiz to claim your CPD certificate;
• Please click on the CPD certificate link below to claim your CPD certificate and to update your CPD Manager.

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