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Modulation of red cell proteasome via redox metabolism, storage, and transfusion.

Expiry Date
: 31/10/2025
CPD Units
: 3.00 Points
Rating
: Not yet rated.

This study characterises how proteasomes change during RBC storage.

Keywords: red cell storage lesion, G6PD deficiency, proteasome, oxidative stress, proteomics and network analyses.

Reading material:

Educational Objectives

Educational Aim:
The aim of this article is to identify variation in both activity levels and protein in the membrane, cytosol and red blood cell-derived extra-cellular vehicles as a function of ex vivo ageing, G6PD- dependent metabolic diversity, and conditions that mimic the bloodstream of the recipient.

Educational Outcomes:
Upon completion of this module practitioners should have a clear understanding of:

  1. Proteasome variations in stored red blood cells
  2. Extracellular proteasomes in the red blood cell units
  3. The effects of storage reversibly or irreversibly on the activity and topology of red blood cell proteasomes.


Instructions for this Module

  • Read the supplied reading material and complete the quiz that follows;
  • You have three attempts to pass the quiz;
  • The pass grade is 70%;
  • You need to pass the quiz to claim your CPD certificate;
  • Please click on the CPD certificate link below to claim your CPD certificate and to update your CPD Manager.

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