Comparison of commercial assays and two-step approach to detect Clostridioides difficile in South Africa

Expiry Date
: 26/06/2029
CPD Units
: 2.00 Points
: Not yet rated.

The article evaluates diagnostic tests for Clostridioides difficile infection, comparing commercial assays and a two-step approach with toxigenic culture. It highlights performance and implications for resource-limited settings.

Keywords: Clostridioides difficile; Clostridium difficile; Xpert; BD MAX; QUIK CHEK; toxigenic culture.

Reading material:

Educational Objectives

Educational Aim:

This study assessed the performance of three commercially available tests and a two-step approach for the diagnosis of C. difficile infection using toxigenic culture (TC) as the gold standard.

Educational Outcomes:
Upon completion of this module practitioners should have a clear understanding of:

  1. Understanding the importance of accurately diagnosing C. difficile infection, especially in hospitals.

  2. Learning about the performance of three tests and a two-step approach for diagnosis, compared to the gold standard test.

  3. Discovering that a two-step approach combining a specific test with another one performs similarly to more expensive tests and could be advantageous in resource-limited settings.

Instructions for this Module

  • Read the supplied reading material and complete the quiz that follows;
  • You have three attempts to pass the quiz;
  • The pass grade is 70%;
  • You need to pass the quiz to claim your CPD certificate;
  • Please click on the CPD certificate link below to claim your CPD certificate and to update your CPD Manager.

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